International Journal of Medicine and Public Health <p><strong>This Page is only for Submissions. For latest and past issues <a href="">CLICK HERE</a></strong></p> <p><strong>International Journal of Medicine and Public Health [IJMEDPH]</strong> [ISSN: 2230–8598]- is a peer-reviewed, international journal, an open-access journal with rapid publication of articles in all fields of Medicine and infectious diseases. The types of article accepted include original articles, review articles, case reports, and letters to the editor. Clinical microbiology relevant immunology, pathophysiology, genetics, epidemiological, and genomics studies are also welcome.</p> <p><strong>Distinctions:</strong> The most widely read, cited, and known Medicine and Public Health journal and website is well browsed with all the articles published. More than 50,000 readers in nearly every country in the world each month<br /><strong>ISSN :</strong> [ISSN:Online - 2230–8598] ; <strong>Frequency: </strong>Rapid at a time publication - Quarterly (4 issues/year)<br /><strong>Rapid publication:</strong> Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.<br /><strong>Abstracting and Indexing Information : </strong>The journal is registered with the following abstracting partners:<br />CNKI (China National Knowledge Infrastructure), EBSCO Publishing's Electronic Databases, Exlibris – Primo Central, Google Scholar, Hinari, Infotrieve, Journal Guide, National Science Library, OpenJGate, ProQuest, TdNet<br />The journal is indexed with, or included in, the following:<br />SCILit, Index Copernicus</p> <p><strong>Open Access Journal: IJMEDPH</strong> is an open access journal, which allows authors to fund their article to be open access in the form publication.</p> EManuscript en-US International Journal of Medicine and Public Health 2230-8598 PROTACs: Opportunities and Challenges Ahead in the Field of Drug Discovery <p class="rtejustify">Proteolysis Targeting Chimeras (PROTACs) are alternatives to traditional small molecule-based drug discovery techniques that focus on direct regulation of protein activity. Targeted protein degradation in cells by heterobifunctional small molecules has emerged as one of the most promising technologies for modulating a protein of interest (POI). PROTACs connect three chemical elements: POI ligand to an E3 ubiquitin ligase (E3) recruiting ligand with an optimal linker for conjugating these two ligands.1 PROTACs cause degradation via the ubiquitinproteasome system (UPS) through proximityinduced ubiquitination of the POI. PROTACs induce target protein degradation at low exposures due to their catalytic mode of action thus making them an attractive platform for cancer therapy and other diseases.&nbsp; <strong>Read more....</strong></p> Anish Kizhakkekkara Vadukoot Copyright (c) 2022 2022-08-01 2022-08-01 12 3 96 96 10.5530/ijmedph.2022.3.19 Breast Feeding and Acute Lymphoblastic Leukaemia in Syria: A Potential Association <p class="rtejustify"><strong>Objectives: </strong>This study aims to assess the interaction between Breastfeeding and ALL incidence and different ALL variables in children. <strong>Methods: </strong>Our case-control study was conducted in the major paediatric cancer centre in Syria. Information was obtained from the hospital’s records of patients who did not have a hereditary or chromosomal syndrome and aged 4 years and less. The cases had ALL and controls were hospital inpatients. Children were divided into 3 groups depending on their feeding habits before the age of 6 months. <strong>Results: </strong>Sixty (85.7%) cases and 59 (72%) controls were exclusively breastfed. Exclusive breastfeeding was found more frequently in the case group P=0.04 (OR, 2.339; CI, 1.025 -5.336). In case group, parents of a low educational level breastfed their children more frequently (P&lt;0.05). Number of siblings was not associated with ALL or any of its variables. Furthermore, infancy feeding pattern correlation with gender, being born with no complications, consanguinity, CD10, FAB classification, ALL-subtype, risk, and family history were insignificant. <strong>Conclusion:</strong> There are certain practices among the Syrian people, especially among parents of a low educational level that has possibly exposed to carcinogenic substances which were possibly transferred through BF. However, BF had minor effects on the prognosis and subtype of ALL, and number of siblings had no effect on ALL.</p> Ameer Kakaje Mohammad Marwan Alhalabi Ayham Ghareeb Bahjat Karam Aya Hamid Bassam Mansour Othman Hamdan Copyright (c) 2022 2022-11-18 2022-11-18 12 3 97 102 10.5530/ijmedph.2022.3.20 Effects of Wood Smoke Exposure and Associated Factors on Respiratory Parameters of Pygmies Involved in the Smoking of Game Meat in the Congo/Brazzaville <p class="rtejustify"><strong>Introduction:</strong> This study assesses the effects of pollutants generated by the burning of firewood by pygmies practicing the smoked meat trade. <strong>Materials and Methods:</strong> A total of 56 rural pygmies aged 36.92 ± 4.69 years old were divided into two groups, whose 29 exposed pygmies (practicing meat smoking) and 27 less exposed pygmies (not practicing this trade). Levels of PM2.5 pollutants and respiratory parameters were measured. A questionnaire including demographic data and another to identify symptoms of respiratory diseases were used. Epi info 7 software was used to perform the analyses. <strong>Results:</strong> This study indicates high concentrations of pollutants in the environment where this occupation is practiced. All spirometric parameters decreased in the exposed pygmies. The symptomatology was chronic cough, shortness of breath, wheezing and dyspnea that were higher in the exposed pygmy group. There was a strong association between the age of the subjects, the duration of exposure and the level of pollutants with certain symptoms. <strong>Conclusion:</strong> These results suggest that pygmies involved in smoking game meat inhale significant quantities of toxic particles. This pollution has health and environmental implications. Screening programmer are needed for this population.</p> Simplice Innocent Moussouami Yvon Rock Ghislain Alongo Florent Nsompi Mack Allah Mack Bio Nigan Issiako François Mbemba Copyright (c) 2022 2022-11-18 2022-11-18 12 3 103 106 10.5530/ijmedph.2022.3.21 Application of Stem Cell Therapy (SCT) to Covid-19: A Scientometric Assessment of Global Publications during 2020-21 <p class="rtejustify"><strong>Objectives: </strong>The study makes a bibliometric evaluation of global publications on “Application of Stem Cell Therapy to Covid-19” during 2020-22. <strong>Methods: </strong>The published publications on this theme were searched, retrieved, and downloaded from the Elsevier’s Scopus international database and analyzed using bibliometric techniques based on select bibliometric indicators. The VOSviewer software and Biblioshiny application were used to construct and visualize bibliometric networks. <strong>Results: </strong>In all 1413 publications were indexed on “Application of Stem Cell Therapy to Covid-19” in the Scopus database till 30 December 2021. These publications registered an average of 18.03 citations per paper. Of these, the funded publications were 452(31.99%). In all, 91 countries, 690 organizations, and 1068 authors participated in global research and published in 317 journals. Among participating countries, China, the U.K., Italy, and India lead in publications output (with 185, 148, 127, and 110 papers) and China (58.38 and 3.24), France (47.0 and 2.61), Netherlands (46.63 and 2.59) and the U.K. (41.84 and 2.32) leads in citation impact. Among participating organizations, Tehran University of Medical Sciences, Iran (37 papers), Harvard Medical School, USA (36 papers), Memorial Sloan Kettering Cancer Center, USA (29 papers) and Shahid Beheshti University of Medical Sciences, Iran (26 papers) leads in publications productivity (with 37, 36, 29 and 26 papers) and Brigham and Women’s Hospital, USA (110.78 and 6.14), Massachusetts General Hospital, USA (81.35 and 4.51), Icahn School of Medicine at Mount Sinai, USA (78.95 and 4.38) and Harvard Medical School, USA (75.42 and 4.18) leads in citation impact. Among participating authors, K.K.Sahu (9 papers), J. Cerny (7 papers), M.A. Perales and M.Z. Ratajzak (7 papers each) leads in publication productivity and M. Mohty (37.0 and 2.05), P.R.M. Rocco (35.8 and 1.99), D.J. Weiss (33.5 and 1.86) and M.A. Perales (32.86 and 1.82) leads in citation impact. <em>Stem Cell Reviews</em> and <em>Reports </em>(35 papers)<em>, Frontiers in</em> <em>Immunology </em>(32 papers), <em>Bone Marrow Transplantation </em>(30 papers) leads in publication productivity and Journal of Medical Virology (132.10), American Journal of Hematology (75.20),<em> Aging and Disease</em> (55.46) and <em>Cell Stem Cell</em> (33.14) leads in citation impact. <strong>Conclusion:</strong> The research is mainly dominated by North America and Western Europe, but with some contribution from China, India, Iran, and Brazil playing also an important role. The developing countries need to prioritize their research in this area and increase their collaboration with North America and Western Europe countries. The analysis will help scholars and policy-makers to take stock of the present situation and decide the future course of action on the “Application of Stem Cells in Covid-19”</p> B M Gupta Mallikarjun Kappi K K Mueen Ahmed Copyright (c) 2022 2022-11-18 2022-11-18 12 3 107 115 10.5530/ijmedph.2022.3.22 The Impact and Sustainability of Hand-hygiene Practices on Health Facilities in the Context of the COVID-19 Pandemic. A Case Study of Busia County (Kenya) <p class="rtejustify"><strong>Introduction: </strong>Health care associated infections including COVID-19 are drawing attention from patients, insurers and Governments worldwide because of the magnitude of the problem i.e. morbidity, mortality and treatment, although these are preventable. Literature review shows there is very little published information on hand washing practices of health care workers in Kenya. This study provides important inputs for planning, policy making and informs future research areas and methods. <strong>Methods: </strong>A cross sectional study design was conducted in Matayos, Teso South and Teso North sub-counties of Busia County. The study covered 33 consenting health workers in 7 health facilities. An interview guide and observation checklist were used to collect data and to ascertain availability of hygiene and sanitation facilities. Thematic analysis was used to analyze qualitative data while quantitative data was analyzed using descriptive statistics.<strong> Results: </strong>That there was no policy on hand hygiene in 6 (86%) health facilities; awareness about hand hygiene was high; knowledge on critical moments for hand hygiene was unsatisfactory but nurses scored better. Only 44% respondents knew effectiveness of alcohol-based sanitizer; on disposal of waste, maternity wards ranked highest 6(87.7%) complying. Laxity in enforcing obligatory use of hand hygiene was high only 2(28.6 %.) of facilities complying. Respondents attributed reduction in diarrheal infections and improvements in sanitation during covid-19 pandemic to rigorous hand hygiene practices. Found that hand hygiene compliance by health care workers can reduce infections in health facilities. That lack of piped water, erratic supply of soap, sanitizers and dependency on external partners were perceived to be important barriers for the sustainability of hand washing practices.<strong> Conclusion:</strong> The hand hygiene initiative has occupied a new and important place in the minds of health workers, policy makers and communities due to its contribution in the prevention and control of one of the most serious diseases of the 21st century. The initiative has presented a compelling case for investment in preventive and promotive health and demonstrated the power of the old adage “prevention is better than cure”. Purposeful partnerships and collaborations are powerful tools to achieve common goals. The study also exposed various systemic weaknesses within the public health sector and the political leadership that needs to be addressed to ensure sustainability of hand hygiene.</p> William Okedi Caroline Wakoli Irene Emojong Copyright (c) 2022 2022-11-18 2022-11-18 12 3 116 130 10.5530/ijmedph.2022.3.23